Today, diabetes is a major public health problem. This disease spares no one, transcends age and national borders, and is reaching alarming proportions, with half a billion people affected worldwide. Type 2 diabetes, the most common form, "can often be prevented and, in some cases, remitted," as Professor Cho, President of the International Diabetes Federation (2017-2019), points out. A silent and painless disease, prevention and self-care remain essential.
Our bodies possess an entire natural defense, repair, and prevention system: bone marrow stem cells. What if their natural mobilization were an ally in these "prevention and remission" actions?
DIABETES in figures?
The 9th edition of the International Diabetes Federation's "Diabetes Atlas" published an update of global figures at the beginning of the year. Diabetes currently affects 463 million people (10.2% of the population) worldwide in 2019, compared to 151 million (4.6%) 20 years ago. Projections are not tending to decrease, with an increase of more than 50% expected by 2045 (700 million). Even if France is not among the top 10 most affected countries, regardless of the type of diabetes and age, it is nonetheless spared.
- 3.48 million adults (20-79 years old)
- 4.8% of the French population
- 1 in 13 people
- 37.6% undiagnosed (unaware)
DIABETES: what is it?
Diabetes is a chronic condition that occurs when our body no longer has the capacity to produce insulin (type 1 diabetes, 10% of cases), or does not produce enough insulin, or when it cannot effectively use the insulin it does produce (type 2 diabetes, 90% of cases).
Insulin is an essential hormone secreted by the pancreas, which, among other things, allows glucose (sugar) to leave the bloodstream and reach the body's cells to nourish them (energy, fuel) and maintain constant blood glucose (blood sugar) levels. These two forms of diabetes are the most common, along with diabetes developed during pregnancy (gestational diabetes). Note that there are other, more complex and rarer forms that we will not discuss here.
In a diabetic, a lack of insulin or its inactivity will lead to an increase in blood sugar levels (hyperglycemia). This chronic hyperglycemia and glycemic variations will be the cause of numerous cardiovascular, neuronal, ocular, renal complications, etc.
Typical symptoms of type 1 diabetes
Stem cells and diabetes?
Every day, in each organ, dying or damaged cells are naturally replaced by other cells arriving through the bloodstream. These are bone marrow stem cells. They have the ability to transform into all cell types (cardiac, pulmonary, vascular, digestive, etc.) and constitute the main natural system for cell renewal and repair.
Learn more: The Fundamental Role of Stem Cells in the Body
To discover natural solutions to support and increase stem cell production, click here.
Health is maintained when there is a perfect balance between the cell loss and renewal systems. However, when an imbalance favoring cell loss occurs, pathologies gradually develop.
In diabetes, for example, a progressive loss of pancreatic cells leads to a decrease in insulin production and an increase in blood sugar. If the number of repair cells is insufficient to repair this damage, chronic hyperglycemia will develop, and this is what is observed as the disease develops and progresses. 3
Even in the pre-diabetic stages (fasting hyperglycemia and impaired glucose tolerance), a lower number of circulating stem cells has been observed compared to non-diabetic individuals. Furthermore, diabetic individuals have, on average, half as many circulating stem cells as non-diabetic individuals. 3 Disease progression is correlated with the number of stem cells. Indeed, as the disease progresses and glycated hemoglobin increases in type 2 diabetics, the number of circulating stem cells is lower. 10 The more advanced the stage, where diabetic vascular complications are accompanied by lesions, the lower the number of stem cells. 11
Stem cell mobilization represents a new therapeutic approach for diabetes. When the number of circulating cells is increased by injection, for example in type 1 diabetics who are therefore insulin-dependent, it has been shown that diabetic patients remain insulin independent 1 year after the stem cell injection. This suggests that the stem cells have regenerated the pancreas sufficiently to restore sufficient insulin production to normally regulate blood sugar. 12 In type 2 diabetic patients, stem cell injections aimed at increasing the number of circulating stem cells are associated with a halving of the daily insulin dose, improved insulin sensitivity, and increased insulin secretion by the pancreas. 13
Meta-analyses—statistical analyses of all clinical studies conducted on type 2 diabetics with stem cell injections—have demonstrated a significant decrease in glycated hemoglobin and hyperglycemia, the two diabetes markers that physicians monitor in their patients. 14 A significant increase in insulin secretion is also observed. Mobilizing stem cells therefore represents an interesting new therapeutic approach in the treatment of diabetes.
Learn more: Stem cells and diabetes: a new natural therapeutic approach
Finally, could these stem cells represent a therapeutic asset in the prevention and support of diabetic care by regenerating the pancreas to restore insulin production and action?
How can stem cell release be stimulated?
Certain natural plants, such as algae, are capable of mobilizing (releasing) stem cells from the bone marrow into the blood, such as AFA (Aphanizomenon flos aquae), spirulina (Arthrospira platensis), or wakame (Undaria pinnatifida).
AFA (Aphanizomenon flos aquae)
AFA is a blue-green algae that grows naturally in Klamath Lake in Oregon, USA. The unique ecosystem in which it thrives provides it with a unique composition of vitamins, minerals, trace elements, and antioxidants, giving it exceptional nutritional value.
A scientific study has demonstrated that consuming an AFA extract allows for the release of 3 to 4 million additional bone marrow stem cells into the blood after 1 hour of consumption. To discover and test natural AFA-based solutions, click here.
To learn more: AFA: a blue-green algae with exceptional nutritional value.
Spirulina
Spirulina is also a blue-green algae. It also has an interesting nutritional profile due to its richness in proteins, vitamins, omega-3s, polyunsaturated fatty acids, essential amino acids, and micronutrients.
It has the ability to increase the amount of signaling molecules (sent by the organ in need of repair) in order to release stem cells from the bone marrow to the initiating organ for repair.
Learn more: The benefits of spirulina
Wakame
Wakame is known for its use in Japanese cuisine, this green algae is more commonly called sea fern. In addition to its immunostimulant action, Wakame extracts rich in fucoidan help stimulate the release of bone marrow stem cells into the bloodstream.
What's new in science?
Numerous scientific evidence indicates that natural compounds, particularly antioxidants (fruits and vegetables, plants, vitamins, minerals, etc.), help limit the complications of diabetes and represent genuine complements to the therapies currently offered to diabetics. 7
As for AFA, its ingestion by diabetic rats demonstrated the ability of pancreatic cells to regenerate and, above all, to function, thus enabling better regulation of the animals' blood sugar levels, with a 50% reduction in fasting hyperglycemia. 8
Even more interesting, in humans, a study demonstrated that consuming AFA for 12 weeks tended to lower fasting blood sugar and significantly decrease glycated hemoglobin (HbA1c), the marker of good blood sugar balance, in type 2 diabetic patients.
Could these algae, natural mobilizers of our repair and defense system, be an ally in preventing diabetes and improving symptoms, allowing them to repair aging or defective cells over time and thus preserve pancreatic function?
Stemenhance Ultra! Slows down the signs of aging
StemEnhance ULTRA supports the body's natural self-healing mechanism by increasing the circulation of healthy adult stem cells.
THE ULTIMATE STEM CELL SUPPORT
Why is it important to support our stem cells?
Stem cells are naturally present in the body and serve to replenish dying or damaged cells.* As we age, our body's ability to self-repair and maintain optimal health diminishes due to a reduction in the number of circulating stem cells associated with the normal aging process. Increasing the number of circulating stem cells is believed to support the body's self-repair and self-renewal processes.*
StemEnhance ULTRA is the most effective stem cell support product available. It contains a proprietary blend of highly concentrated extracts, including Fucoidan and the exclusive ingredients StemEnhance and Mesenkine®.
PRODUCT BENEFITS | ADULT STEM CELLS
WHAT ARE ADULT STEM CELLS?
They are undifferentiated cells that multiply by cell division to replenish dying cells and regenerate damaged tissue. (They can become any type of cell (skin, bone, liver, heart, lung, for example) and replicate throughout an organism's life.
WHAT ARE THEY USED FOR?
They repair and regenerate the body.
WHAT ARE THE BENEFITS OF HAVING MORE ADULT STEM CELLS?
Studies show that a higher number of circulating adult stem cells is one of the most beneficial factors for optimal health.
An increase in the number of adult stem cells gives our body more resources to repair, recover, and rebuild. The rate of natural release of adult stem cells from the bone marrow decreases with age.
- At age 35, the rate of natural stem cell release drops by 45%.
- At age 50, the rate of natural stem cell release drops by 50%.
- At age 65, the rate of natural stem cell release drops by 90%.
All cells in our body have a limited lifespan. Some cells live for a few days, others for weeks, months, and some for years.
Vitamins, minerals, antioxidants, and a good diet nourish and protect our cells. However, no matter how well you nourish and protect your cells, they will eventually die, and only your adult stem cells will replace these dying cells with brand new, healthy ones.
StemEnhance ULTRA is made from pristine natural “superfoods.”
StemEnhance ULTRA (SEU) is composed of nature's most primal superfoods. It concentrates and combines extracts of freshwater microalgae and marine macroalgae. Cerule specializes in harvesting Aphanizomenon flos aquae (AFA) and processing and extracting AFA and spirulina using processes that guarantee quality from raw material to finished product. SEU is the result of more than 10 years of research into the identification and extraction of active molecules, as well as the development of a proprietary drying technology called HydroDry®, which preserves the nutritional benefits of algae (US Patents 6,814,961 & 9,370,537 / EU Patent 1,895,973).
StemEnhance ULTRA, a patented and clinically tested AFA extract, is combined with Fucoidan from Undaria pinnatifida and Mesenkine, a Spirulina concentrate exclusive and patented by Cerule. These three ingredients work synergistically to promote the release of your adult stem cells.
Aphanizomenon flos aquae (AFA) is a blue-green algae from the cyanobacteria family that grows naturally in Klamath Lake in southern Oregon. Located in the heart of a volcanic region and a preserved natural park, Klamath Lake is a unique ecosystem rich in sediments and minerals, conducive to the growth of the algae. It provides a full range of macronutrients and micronutrients (Pietri A. M., 2011). Indeed, it is composed of more than 50% protein and approximately 8% fiber, for example. It is also rich in micronutrients. It is a source of:
- 20 amino acids, including 10 essential ones, characterized by an ideal profile given the recommended daily intake.
- 60 minerals and trace elements, notably its high calcium (6 mg/g) and iron (0.32 mg/g).
- 14 vitamins, including vitamins B1, B2, and B12 in particular.
It also provides multiple antioxidants such as carotenoids, lycopene, and chlorophyll, and also contains PhenylEthylAmine (PEA). This molecule is naturally produced by the body during periods of positive emotions, helping to regulate mood.
StemEnhance® (Aphanizomenon flos aquae)
StemEnhance contains an L-selectin inhibitor and has been clinically tested to promote the mobilization of your adult stem cells (Jensen et al., 2007). The extract has been extensively studied in several preclinical and clinical studies (Drapeau et al., 2010; Drapeau et al., 2012; Ismail et al. 2013; El Akabawy & El Mehi 2015).
AFA is well known for its nutritional richness in macro- and micronutrients. It is composed of 60% protein and 14% carbohydrates. It is also rich in certain polyunsaturated fatty acids, amino acids, and micronutrients such as iron, calcium, magnesium, phosphorus, and selenium. It is used as a nutritional supplement worldwide. It contains antioxidants and supports immune function (Finamore et al., 2017).
Mesenkine® (Arthrospira Platensis)
Mesenkine: During the development of Cyactiv®, a low-molecular-weight yellow compound called Mesenkine was discovered and isolated from spirulina.
The extraction and manufacturing process has been patented by Cerule. Ongoing research has revealed that this compound may help mobilize your stem cells.
Fucoïdan (Undaria pinnatifida)
Fucoidan is known in Japanese cuisine as wakame. This seaweed is found in Japanese restaurants in salad form or in miso soup. Undaria pinnatifida is a brown seaweed commonly known as sea fern.
It grows in several regions of the world, but the wakame selected for the SEU comes from the world's most pristine ocean environments. Undaria pinnatifida can protect cells and tissues from damage caused by oxidative stress.
Indeed, this seaweed contains antioxidants, the main ones being polyphenols and fucoxanthin (Fung et al., 2013). This property is the result of an adaptive defense mechanism since marine algae are exposed to large amounts of light and oxygen.
Marine algae such as wakame are also known for their rich polysaccharide content in their cell walls. Fucoidan is one of these polysaccharides. Cerule uses a purified extract of over 80% fucoidan. This polysaccharide helps stimulate the mobilization of your source of well-being (Irhimeh et al., 2007).
Science to support it !
StemEnhance ULTRA is the result of over 18 years of research. It is the most effective, scientifically validated wellness product available on the market today. Through multiple clinical trials, StemEnhance ULTRA has been documented to optimize stem cell function in the body by increasing their circulating quantity, thus promoting optimal renewal. StemEnhance also contains Mesenkine, which has been shown to increase the blood concentration of G-CSF, which plays a role in stem cell release.
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